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KMID : 0387820070140010068
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Clinical Pediatric Hematology-Oncology
2007 Volume.14 No. 1 p.68 ~ p.72
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Unrelated Cord Blood Transplantation Using Non-TBI Conditioning Regimen in a Child with Fanconi Anemia
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Park Seong-Shik
Park Ji-Ae
Lim Young-Tak
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Abstract
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Fanconi anemia is an autosomal recessive disorder characterized by progressive bone marrow failure, growth retardation, abnormal skin pigmentation, developmental anomalies and marked predisposition to myelodysplastic syndrome or acute myeloid leukemia. Allogeneic hematopoietic stem cell transplantation offers the only curative treatment for bone marrow complications of these patients. Recently umbilical cord blood transplantation has been tried as a successful alternative to bone marrow transplantation in patients with Fanconi anemia, but the results are somewhat disappointing yet. In this report, we describe a case of unrelated HLA 1 antigen mismatched cord blood transplantation using non-TBI conditioning regimen in a 6-year-old boy with Fanconi anemia who is alive with a perfect performance status and normal blood count currently 17 months after the transplantation.
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KEYWORD
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Fanconi anemia, Unrelated cord blood transplantation
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